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program to discover novel small molecule treatments against undisclosed drug targets specified by Novartis using Ensemble's proprietary drug discovery platforms.

"We are very pleased to enter into this collaboration with Novartis, a clear Fendi Handbag Shop Online

CAMBRIDGE, Mass. Ensemble Therapeutics, a biotechnology company developing Ensemblins, a novel class of small molecule therapeutics with the power of biologics, today announced the initiation of a two part research and development collaboration with Novartis. The companies have entered into a strategic development agreement for Ensemble's most advanced proprietary program that targets the inflammatory cytokine IL 17, and for a new Fendi Monster Wallet Uk

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´╗┐In High Demand Ensemble Therapeutics Corporation Picks Novartis AG to Develop Oral Mid Sized Inflammation Drugs

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Under the terms of the agreement, Ensemble will receive an undisclosed upfront payment from Novartis and is also eligible to receive potential success based development and sales milestone payments. In addition, Ensemble will receive tiered royalties on potential future sales of products that may arise from the collaboration. Novartis will also provide research funding to Ensemble during the term of the collaboration.

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Ensemble Therapeutics Corporation, Boehringer Ingelheim Corporation Ink $186 Milliion Macrocycle Drug Pact Celgene Corporation (CELG) Emerges as Biotech's Shrewdest, Nimblest Dealmaker

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end of 2013.

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Ensemblins are a new class of synthetic macrocycles developed by Ensemble using its proprietary chemistry platforms, including DNA Programmed Chemistry. Macrocyclic rings are found in many natural product based drugs and bestow favorable pharmaceutical properties and powerful protein surface binding properties upon such drugs. Thus, macrocycles are uniquely suited to address many protein targets that cannot be modulated effectively by traditional small molecule pharmaceutical compounds. Macrocycles have been challenging to synthesize in large numbers and this has constrained their wider use in the industry. By extending beyond the limits of traditional small molecule drug discovery, Ensemble's platform provides unmatched capabilities to successfully and reliably generate millions of macrocyclic Ensemblins as drug candidates, larger than any collection previously synthesized in the pharmaceutical industry.

leader in the development of treatments for IL 17 dependent inflammation and autoimmune diseases," said Ensemble CEO Michael D. Taylor, PhD. "Novartis has recognized the strength of Ensemble's orally bioavailable drug candidates against this difficult to drug protein:protein interaction target, and we believe Novartis is the best suited pharmaceutical company to partner with us to rapidly develop and market important new medicines for the treatment of IL 17 mediated disease," he continued. "The discovery component of our alliance reinforces the mutual commitment to advance candidates from Ensemble's macrocycle based chemistry."

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Based in Cambridge, MA, Ensemble Therapeutics is deploying its proprietary chemistry platforms to develop a novel class of Fendi Monster Credit Card Holder therapeutics known as "Ensemblins". Ensemble is leveraging its macrocycle drug discovery expertise to fuel its proprietary drug candidate pipeline while also pursuing collaborations with pharmaceutical partners. Prior to this agreement, Ensemble entered high value partnerships including alliances with Boehringer Ingelheim, Genentech, Bristol Myers Squibb, Alexion Pharmaceuticals and Pfizer to access Ensemble's macrocycle libraries for purposes of affinity screening drug discovery against difficult to address targets. Ensemble's internal discovery and development efforts are focused on the key therapeutic areas of oncology and immuno inflammatory diseases, with its lead program, a small molecule antagonist of Interleukin 17, a cytokine implicated in multiple inflammatory and autoimmune diseases, poised to enter development with an orally active candidate by the Fendi Monster Bag Grey

Ensemble's class of IL 17 antagonists licensed by Novartis represent the potential for first in class, orally active, small molecule inhibitors of this important, clinically validated target. The protein protein nature of interaction of IL 17 with its receptor has made design of traditional small molecule pharmaceutical inhibitor difficult, so has been addressed to date with injectable protein therapeutics directed to the ligand. An orally active inhibitor of IL 17 would have a profile complementary to the current class of clinical stage anti IL 17 antibody products, which have shown compelling efficacy in multiple human clinical trials involving various inflammatory and autoimmune diseases.

Ensemble Therapeutics Forms Global Strategic Collaboration for Development of Oral, Macrocyclic IL 17 Antagonists and Additional Disease Targets

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