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´╗┐International Stem Cell Corporation Completes Pre IND Meeting With FDA For Parkinsons Disease Cell Therapy

Statements pertaining to anticipated developments, expected progress of our Parkinson's disease research and development program, and other opportunities for the company and its subsidiaries, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates,") should also Fendi Backpack Men be considered to be forward looking statements. Forward looking statements involve risks and uncertainties, including, without limitation, risks inherent in clinical trials and the development and/or commercialization of potential products, the management of collaborations, regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. Simon Craw

Chief Scientific Officer

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According to the Parkinson's Disease Foundation, an estimated seven to 10 million people worldwide live with PD, with as many as one million of those in the United States alone, more than the combined total of people diagnosed with multiple sclerosis, muscular distrophy, and Lou Gehrig's disease. The total direct and indirect cost of Parkinson's disease is estimated to be nearly $25 billion per year in the United States alone.

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International Stem Cell Corporation's Co Chairman and CEO Andrey Semechkin PhD Publishes Letter To Shareholders BioMarin Pharmaceutical Inc. (BMRN) Announces Selection Of NAGLU Fusion Protein Drug Development Candidate BMN 250 For The Treatment Of Sanfilippo B (MPS IIIB)

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About International Stem Cell Corporation

"We're pleased with the outcomes of the meeting with the FDA," said Yale School of Medicine Professor D. Eugene Redmond Jr. MD, who is leading ISCO's pharmacology/toxicology study. "The FDA's feedback has provided clear direction for the remaining studies required for the IND."

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A more complete description of the hPNSC product and the GMP (21CFR211) manufacturing method was published together with Prof. Evan Y. Snyder, Director of Stem Cell Research Center at Sanford Burnham Medical Research Institute in early 2013. Importantly, unlike many other stem cell therapy products, ISCO's proprietary hPNSC are cryopreservable, meaning they can be delivered in a frozen state to hospitals and clinics.

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Corporation is focused on the therapeutic applications of human parthenogenetic stem cells (hpSCs) and the development and commercialization of cell based research and cosmetic products. ISCO's core technology, parthenogenesis, results in the creation of pluripotent Fendi Bags Macy's

"As this will be the first IND for the Company, we're pleased to have completed this critical milestone," said Dr. Ruslan Semechkin, Chief Scientific Officer of ISCO. "Based on data from our pilot studies, along with the guidance from the FDA, we believe that we're well positioned to successfully transition this program to the clinical stage."

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Dr. Ruslan Semechkin

Executive Vice President

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human stem cells from unfertilized oocytes (eggs) hence avoiding ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenetic, homozygous stem cell line that can be a source of therapeutic cells for hundreds of millions of individuals of differing genders, ages and racial background with minimal immune rejection after transplantation. hpSCs offer the potential to create the first true stem cell bank, UniStemCellTM. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology (

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Following this meeting, ISCO will be working to complete the Good Laboratory Practice (GLP) pharmacology and safety studies, including tumorigenicity, toxicology and tolerability, using the human parthenogenetic neural stem cell (hPNSC) product, a type of self renewing multipotent cell that is a precursor for the major cells of the central nervous system. To date pre clinical pilot studies in rodents and primates Fendi Monster Tote Sale

have shown the hPNSC to be safe, well tolerated, and provide therapeutic benefit by differentiating into dopaminergic neurons and expressing specific neurotrophic factors to protect the nigrostriatal system of the brain. We anticipate being able to report interim primate data before the end of March 2014 and top line final results from these GLP studies later in 2014 and expect to file the IND soon thereafter.

International Stem Cell Corporation Announces $10.25 Million Purchase Agreement With Lincoln Park Capital Fund, LLC Regado Biosciences, Inc. (RGDO), Announces FDA Acceptance Of IND For REG2

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